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09/09/2010
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New drugs and new approaches for the treatment of metastatic urothelial cancer

Calabro F, Sternberg CN
Vincenzo Pansadoro Foundation, Clinic Pio XI, Via Aurelia 559, Rome, Italy 00165
The median survival of patients with metastatic bladder cancer treated with M-VAC is approximately 1 year and long-term survival occurs in a small proportion of patients. Recent efforts to improve the outcome of patients with metastatic transitional cell carcinoma have focused on identifying new drugs with single agent activity and on their incorporation into platinum-based combination regimens. Paclitaxel, docetaxel, ifosfamide and gemcitabine are among the most active new agents. A large number of phase I-II trials have evaluated these agents in two- and three-drug combination regimens. The response proportion observed with these combinations varies considerably and median survival times range from 8 to 20 months. A better understanding of the molecular biology of bladder cancer will undoubtedly influence the selection of new therapeutic modalities. Molecular targeted small molecule therapy and monoclonal antibodies have begun to dominate contemporary studies. Whether or not this approach to therapy will lead to better results must still be determined.
World J Urol. 2002 Aug;20(3):158-66. Epub 2002 Jul 13

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FOUNDATION CONGRESSES

Challenges in Laparoscopy & Robotics 2010: The European Congress of Laparoscopy
Rome, 10-12 June 2010
Challenges in Laparoscopy and Robotics: Urologist learn from frontiers specialties. Surgeons: Claude Abbou, Vincenzo Disanto, Jean-Louis Dulucq, Richard Gaston, Inderbir Gill, Till Holger, Günter Janetschek, Vito Pansadoro, Thierry Piechaud, Jens Rassweiler, Emanuel, Santoro, Jens-Uwe Stolzenburg, Roland Van Velthoven, Arnaud Wattiez, Italian surgeons
Rome, 5-6-7 June 2008
Challenges in Laparoscopy 2007. Surgeons: Claude Abbou, Renaud Bollens, Vincenzo Disanto, Richard Gaston, Inderbir Gill, Giorgio Guazzoni, Bertrand Guillonneau, Jean-Luc Hoepffner, Günter Janetschek, Vito Pansadoro, Thierry Piechaud, Roland Van Velthoven, Ingolf Türk
Bordeaux, France, June 7-8-9 2007
Challenges in Laparoscopy 2006. Guest Surgeons: Renaud Bollens, Richard Gaston, Guenter Janetschek e Peter Schulam
Rome, June 5-6-7 2006
Challenges in Laparoscopy 2005. Live Surgery: Claude Abbou, Richard Gaston, Jens Uwe Stolzenburg
Rome, June 3-4 2005
MORE CONGRESSES

ECCO 14
Barcellona, 23 - 27 Settembre 2007
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